Your browser doesn't support javascript.
loading
Mechanistic rationales for combining immunotherapy with radiotherapy.
Chi, Alexander; Nguyen, Nam Phong.
Afiliação
  • Chi A; Department of Radiation Oncology, Capital Medical University Xuanwu Hospital, Beijing, China.
  • Nguyen NP; School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Front Immunol ; 14: 1125905, 2023.
Article em En | MEDLINE | ID: mdl-37377970
Immunotherapy consisted mainly of immune checkpoint inhibitors (ICIs) has led to significantly improved antitumor response. However, such response has been observed only in tumors possessing an overall responsive tumor immune micro-environment (TIME), in which the presence of functional tumor-infiltrating lymphocytes (TILs) is critical. Various mechanisms of immune escape from immunosurveillance exist, leading to different TIME phenotypes in correlation with primary or acquired resistance to ICIs. Radiotherapy has been shown to induce antitumor immunity not only in the irradiated primary tumor, but also at unirradiated distant sites of metastases. Such antitumor immunity is mainly elicited by radiation's stimulatory effects on antigenicity and adjuvanticity. Furthermore, it may be significantly augmented when irradiation is combined with immunotherapy, such as ICIs. Therefore, radiotherapy represents one potential therapeutic strategy to restore anti-tumor immunity in tumors presenting with an unresponsive TIME. In this review, the generation of anti-tumor immunity, its impairment, radiation's immunogenic properties, and the antitumor effects of combining radiation with immunotherapy will be comprehensively discussed.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoterapia / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoterapia / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article