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Pericytes Are Not Associated With Reduced Capillary Perfusion After Experimental Subarachnoid Hemorrhage.
Schwarting, Julian; Nehrkorn, Katrin; Harapan, Biyan N; Balbi, Matilde; Terpolilli, Nicole A; Plesnila, Nikolaus.
Afiliação
  • Schwarting J; Institute for Stroke and Dementia Research (ISD) (J.S., K.N., B.N.H., M.B., N.T., N.P.), Munich University Hospital, Germany.
  • Nehrkorn K; Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Germany (J.S.).
  • Harapan BN; Institute for Stroke and Dementia Research (ISD) (J.S., K.N., B.N.H., M.B., N.T., N.P.), Munich University Hospital, Germany.
  • Balbi M; Munich Cluster for System Neurology (SyNergy), Germany (K.N., M.B., N.T., N.P.).
  • Terpolilli NA; Institute for Stroke and Dementia Research (ISD) (J.S., K.N., B.N.H., M.B., N.T., N.P.), Munich University Hospital, Germany.
  • Plesnila N; Department of Neurosurgery (B.N.H., N.T.), Munich University Hospital, Germany.
Stroke ; 54(8): 2172-2177, 2023 08.
Article em En | MEDLINE | ID: mdl-37381898
BACKGROUND: Subarachnoid hemorrhage (SAH) is characterized by an acute reduction of cerebral blood flow and subsequent cortical infarcts, but the underlying mechanisms are not well understood. Since pericytes regulate cerebral perfusion on the capillary level, we hypothesize that pericytes may reduce cerebral perfusion after SAH. METHODS: Pericytes and vessel diameters of cerebral microvessels were imaged in vivo using NG2 (neuron-glial antigen 2) reporter mice and 2-photon microscopy before and 3 hours after sham surgery or induction of SAH by perforating the middle cerebral artery with an intraluminal filament. Twenty-four hours after, SAH pericyte density was assessed by immunohistochemistry. RESULTS: SAH caused pearl-string-like constrictions of pial arterioles, slowed down blood flow velocity in pial arterioles by 50%, and reduced the volume of intraparenchymal arterioles and capillaries by up to 70% but did not affect pericyte density or induce capillary constriction by pericytes. CONCLUSIONS: Our results suggest that perfusion deficits after SAH are not induced by pericyte-mediated capillary constrictions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemorragia Subaracnóidea / Pericitos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemorragia Subaracnóidea / Pericitos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article