Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors.

Hussain, Muhammad S; Liu, Degang; Alilain, Warren J; Meroueh, Samy O

Hussain, Muhammad S; Liu, Degang; Alilain, Warren J; Meroueh, Samy O.

Afiliação

Hussain MS; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Liu D; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Alilain WJ; Spinal Cord and Brain Injury Center, University of Kentucky, Lexington, Kentucky 40506, United States.
Meroueh SO; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.

ACS Chem Neurosci ; 14(14): 2509-2516, 2023 07 19.

Article em En | MEDLINE | ID: mdl-37382289

Assuntos

Fatores de Troca do Nucleotídeo Guanina; Guanina; Humanos; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Proteínas rho de Ligação ao GTP/metabolismo; Nucleotídeos/metabolismo

Palavras-chave

Rac1; Rho GTPases; RhoA; covalent inhibitor; guanine exchange factor; small molecule

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Troca do Nucleotídeo Guanina / Guanina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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