Imputation of low-coverage sequencing data from 150,119 UK Biobank genomes.
Nat Genet
; 55(7): 1088-1090, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37386250
ABSTRACT
The release of 150,119 UK Biobank sequences represents an unprecedented opportunity as a reference panel to impute low-coverage whole-genome sequencing data with high accuracy but current methods cannot cope with the size of the data. Here we introduce GLIMPSE2, a low-coverage whole-genome sequencing imputation method that scales sublinearly in both the number of samples and markers, achieving efficient whole-genome imputation from the UK Biobank reference panel while retaining high accuracy for ancient and modern genomes, particularly at rare variants and for very low-coverage samples.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Bancos de Espécimes Biológicos
/
Polimorfismo de Nucleotídeo Único
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article