Lopinavir and ritonavir act synergistically with azoles against Candida auris in vitro and in a mouse model of disseminated candidiasis.

Salama, Ehab A; Eldesouky, Hassan E; Elgammal, Yehia; Abutaleb, Nader S; Seleem, Mohamed N

Salama, Ehab A; Eldesouky, Hassan E; Elgammal, Yehia; Abutaleb, Nader S; Seleem, Mohamed N.

Afiliação

Salama EA; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
Eldesouky HE; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
Elgammal Y; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
Abutaleb NS; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
Seleem MN; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia. Electronic addre

Int J Antimicrob Agents ; 62(3): 106906, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37392947

Assuntos

Candidíase; Inibidores da Protease de HIV; Animais; Camundongos; Antifúngicos/farmacologia; Antifúngicos/uso terapêutico; Ritonavir/uso terapêutico; Azóis/farmacologia; Azóis/uso terapêutico; Itraconazol/farmacologia; Itraconazol/uso terapêutico; Lopinavir/farmacologia; Lopinavir/uso terapêutico; Candida auris; Inibidores da Protease de HIV/farmacologia; Inibidores da Protease de HIV/uso terapêutico; Candidíase/tratamento farmacológico; Candidíase/microbiologia; Testes de Sensibilidade Microbiana; Farmacorresistência Fúngica

Palavras-chave

Azole resistance; Candida auris; Checkerboard assay; HIV protease inhibitors; In vivo infection model

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Candidíase / Inibidores da Protease de HIV Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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