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Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.
Beusch, Irene; Rao, Beiduo; Studer, Michael K; Luhovska, Tetiana; Sukyte, Viktorija; Lei, Susan; Oses-Prieto, Juan; SeGraves, Em; Burlingame, Alma; Jonas, Stefanie; Madhani, Hiten D.
Afiliação
  • Beusch I; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA.
  • Rao B; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA.
  • Studer MK; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, Zurich, Switzerland.
  • Luhovska T; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, Zurich, Switzerland.
  • Sukyte V; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, Zurich, Switzerland.
  • Lei S; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA.
  • Oses-Prieto J; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA.
  • SeGraves E; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA.
  • Burlingame A; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA.
  • Jonas S; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zurich, Zurich, Switzerland.
  • Madhani HD; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA. Electronic address: hitenmadhani@gmail.com.
Mol Cell ; 83(14): 2578-2594.e9, 2023 07 20.
Article em En | MEDLINE | ID: mdl-37402368

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Spliceossomos / Compostos de Epóxi Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Spliceossomos / Compostos de Epóxi Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article