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The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.
Qiu, Xianxiu; Li, Na; Yang, Qifan; Wu, Shuai; Li, Xiaohua; Pan, Xuehua; Yamamoto, Soh; Zhang, Xiaozhe; Zeng, Jincheng; Liao, Jiahao; He, Congcong; Wang, Renxiao; Zhao, Yanxiang.
Afiliação
  • Qiu X; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.
  • Li N; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, the First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
  • Yang Q; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.
  • Wu S; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, P.R. China.
  • Li X; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China.
  • Pan X; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Yamamoto S; Department of Research and Development, Shenzhen Shiningbiotek Co. Ltd, Shenzhen, P. R. China.
  • Zhang X; Shenzhen Pengcheng Biopharm Co. Ltd, Shenzhen, P.R. China.
  • Zeng J; Department of Cell and Molecular Biology, Feingberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Liao J; Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.
  • He C; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, P.R. China.
  • Wang R; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, the First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
  • Zhao Y; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, the First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
Autophagy ; 19(11): 2884-2898, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37409929
ABBREVIATIONS: AMBRA1 autophagy and beclin 1 regulator 1; ATG14 autophagy related 14; ATG5 autophagy related 5; ATG7 autophagy related 7; BECN1 beclin 1; BECN2 beclin 2; CC coiled-coil; CQ chloroquine CNR1/CB1R cannabinoid receptor 1 DAPI 4',6-diamidino-2-phenylindole; dCCD delete CCD; DRD2/D2R dopamine receptor D2 GPRASP1/GASP1 G protein-coupled receptor associated sorting protein 1 GPCR G-protein coupled receptor; ITC isothermal titration calorimetry; IP immunoprecipitation; KD knockdown; KO knockout; MAP1LC3/LC3 microtubule associated protein 1 light chain 3; NRBF2 nuclear receptor binding factor 2; OPRD1/DOR opioid receptor delta 1 PIK3C3/VPS34 phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3R4/VPS15 phosphoinositide-3-kinase regulatory subunit 4; PtdIns3K class III phosphatidylinositol 3-kinase; PtdIns3P phosphatidylinositol-3-phosphate; RUBCN rubicon autophagy regulator; SQSTM1/p62 sequestosome 1; UVRAG UV radiation resistance associated; VPS vacuolar protein sorting; WT wild type.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article