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Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain.
Harris, Noah J; Jenkins, Meredith L; Nam, Sung-Eun; Rathinaswamy, Manoj K; Parson, Matthew A H; Ranga-Prasad, Harish; Dalwadi, Udit; Moeller, Brandon E; Sheeky, Eleanor; Hansen, Scott D; Yip, Calvin K; Burke, John E.
Afiliação
  • Harris NJ; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Jenkins ML; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Nam SE; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada.
  • Rathinaswamy MK; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Parson MAH; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Ranga-Prasad H; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Dalwadi U; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada.
  • Moeller BE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Sheeky E; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Hansen SD; Department of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon, Eugene, United States.
  • Yip CK; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada.
  • Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
Elife ; 122023 Jul 07.
Article em En | MEDLINE | ID: mdl-37417733
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2023 Tipo de documento: Article