MiR-494-3p aggravates pirarubicin-induced cardiomyocyte injury by regulating MDM4/p53 signaling pathway.

Huang, Peng; Zhang, Yibing; Wang, Fengjun; Qin, Meng; Ma, Jiulong; Ji, Jiahua; Wei, Dexian; Ren, Liqun

Huang, Peng; Zhang, Yibing; Wang, Fengjun; Qin, Meng; Ma, Jiulong; Ji, Jiahua; Wei, Dexian; Ren, Liqun.

Afiliação

Huang P; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.
Zhang Y; Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China.
Wang F; Department of Hepatobiliary Surgery, Songyuan Central Hospital, Songyuan, China.
Qin M; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.
Ma J; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.
Ji J; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.
Wei D; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.
Ren L; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.

Environ Toxicol ; 38(10): 2499-2508, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37421283

Assuntos

MicroRNAs; Transdução de Sinais; Camundongos; Animais; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Miócitos Cardíacos; Cardiotoxicidade/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Apoptose

Palavras-chave

HL-1 cardiac muscle cell; cardiotoxicity; miR-494-3p; miR-494-3p/MDM4/p53; pirarubicin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / MicroRNAs Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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