Hit 'em Where It Hurts: Gram-Negative Bacterial Lipopolysaccharide as a Vaccine Target.
Microbiol Mol Biol Rev
; 87(3): e0004522, 2023 09 26.
Article
em En
| MEDLINE
| ID: mdl-37432116
ABSTRACT
Infections with antimicrobial-resistant (AMR) bacteria pose an increasing threat to the ability to perform surgical procedures, organ transplantation, and treat cancer among many other medical conditions. There are few new antimicrobials in the development pipeline. Vaccines against AMR Gram-negative bacteria may reduce the use of antimicrobials and prevent bacterial transmission. This review traces the origins of lipopolysaccharide (LPS)-based vaccines against Gram-negative bacteria, the role of O polysaccharides and LPS core regions as potential vaccine targets, the development of new vaccine technologies, and their application to vaccines in current development.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Infecções por Bactérias Gram-Negativas
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article