The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery.
Geroscience
; 45(6): 3103-3113, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37432607
ABSTRACT
Targeting aging is the future of twenty-first century preventative medicine. Small molecule interventions that promote healthy longevity are known, but few are well-developed and discovery of novel, robust interventions has stagnated. To accelerate longevity intervention discovery and development, high-throughput systems are needed that can perform unbiased drug screening and directly measure lifespan and healthspan metrics in whole animals. C. elegans is a powerful model system for this type of drug discovery. Combined with automated data capture and analysis technologies, truly high-throughput longevity drug discovery is possible. In this perspective, we propose the "million-molecule challenge", an effort to quantitatively assess 1,000,000 interventions for longevity within five years. The WormBot-AI, our best-in-class robotics and AI data analysis platform, provides a tool to achieve the million-molecule challenge for pennies per animal tested.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Robótica
/
Longevidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article