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Advances in Central Nervous System Tumor Classification.
Malta, Tathiane M; Snyder, James; Noushmehr, Houtan; Castro, Ana Valeria.
Afiliação
  • Malta TM; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
  • Snyder J; Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA.
  • Noushmehr H; Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA. hnoushm1@hfhs.org.
  • Castro AV; Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA.
Adv Exp Med Biol ; 1416: 121-135, 2023.
Article em En | MEDLINE | ID: mdl-37432624
Historically, the classification of tumors of the central nervous system (CNS) relies on the histologic appearance of cells under a microscope; however, the molecular era of medicine has resulted in new diagnostic paradigms anchored in the intrinsic biology of disease. The 2021 World Health Organization (WHO) reformulated the classification of CNS tumors to incorporate molecular parameters, in addition to histology, to define many tumor types. A contemporary classification system with integrated molecular features aims to provide an unbiased tool to define tumor subtype, the risk of tumor progression, and even the response to certain therapeutic agents. Meningiomas are heterogeneous tumors as depicted by the current 15 distinct variants defined by histology in the 2021 WHO classification, which also incorporated the first moelcular critiera for meningioma grading: homozygous loss of CDKN2A/B and TERT promoter mutation as criteria for a WHO grade 3 meningioma. The proper classification and clinical management of meningioma patients requires a multidisciplinary approach, which in addition to the information on microscopic (histology) and macroscopic (Simpson grade and imaging), should also include molecular alterations. In this chapter, we present the most up-to-date knowledge in CNS tumor classification, particularly in meningioma, in the molecular era and how it could affect their future classification and clinical management of patients with these diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Central / Neoplasias Meníngeas / Meningioma Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Central / Neoplasias Meníngeas / Meningioma Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article