Characterizing metal-biomolecule interactions by mass spectrometry.
Trends Biochem Sci
; 48(9): 815-825, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37433704
ABSTRACT
Metal micronutrients are essential for life and exist in a delicate balance to maintain an organism's health. The labile nature of metal-biomolecule interactions clouds the understanding of metal binders and metal-mediated conformational changes that are influential to health and disease. Mass spectrometry (MS)-based methods and technologies have been developed to better understand metal micronutrient dynamics in the intra- and extracellular environment. In this review, we describe the challenges associated with studying labile metals in human biology and highlight MS-based methods for the discovery and study of metal-biomolecule interactions.
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Base de dados:
MEDLINE
Assunto principal:
Metais
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article