A Rare Hemoglobin Variant Detected in a Pregnant Chinese Woman.
Clin Lab
; 69(7)2023 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-37436392
ABSTRACT
BACKGROUND:
Hemoglobin Variant (HBBc.155 C>A) is a rare mutation caused by ß-globin gene mutation called Hemoglobin North Manchester. So far, its existence has no adverse effect on human body, and it is a rare benign hemoglobin variant.METHODS:
We reported a 32-year-old pregnant woman with discordant HbA1c and glucose measurements. In 75 g oral glucose tolerance test (OGTT), the pregnant woman got hyperglycemia at 1h-OGTT and 2h-OGTT. However, the pregnant woman had a low HbA1c of 3.9%. Subsequently, gene sequencing identified a rare mutation in the gene (HBBc.155 C>A).RESULTS:
We report for the first time that a case of North Manchester mutation in a Chinese female patient. In this case, it was found that the North Manchester variant could affect the examination of HbA1c when measured by ion-exchange high-performance liquid chromatography (HPLC), causing in falsely low HbA1c.CONCLUSIONS:
Hemoglobin variants may lead to false HbA1c measurement. Clinicians should consider hemoglobin variants when HbA1c results are inconsistent with other laboratory tests.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas Anormais
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article