Are individual-level risk factors for gastroschisis modified by neighborhood-level socioeconomic factors?
Birth Defects Res
; 115(15): 1438-1449, 2023 09 01.
Article
em En
| MEDLINE
| ID: mdl-37439400
ABSTRACT
BACKGROUND:
Two strong risk factors for gastroschisis are young maternal age (<20 years) and low/normal pre-pregnancy body mass index (BMI), yet the reasons remain unknown. We explored whether neighborhood-level socioeconomic position (nSEP) during pregnancy modified these associations.METHODS:
We analyzed data from 1269 gastroschisis cases and 10,217 controls in the National Birth Defects Prevention Study (1997-2011). To characterize nSEP, we applied the neighborhood deprivation index and used generalized estimating equations to calculate odds ratios and relative excess risk due to interaction.RESULTS:
Elevated odds of gastroschisis were consistently associated with young maternal age and low/normal BMI, regardless of nSEP. High-deprivation neighborhoods modified the association with young maternal age. Infants of young mothers in high-deprivation areas had lower odds of gastroschisis (adjusted odds ratio [aOR] 3.1, 95% confidence interval [CI] 2.6, 3.8) than young mothers in low-deprivation areas (aOR 6.6; 95% CI 4.6, 9.4). Mothers of low/normal BMI had approximately twice the odds of having an infant with gastroschisis compared to mothers with overweight/obese BMI, regardless of nSEP (aOR range 1.5-2.3).CONCLUSION:
Our findings suggest nSEP modified the association between gastroschisis and maternal age, but not BMI. Further research could clarify whether the modification is due to unidentified biologic and/or non-biologic factors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gastrosquise
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Infant
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Pregnancy
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article