PARP inhibitor exerts an anti-tumor effect via LMO2 and synergizes with cisplatin in natural killer/T cell lymphoma.

Wu, Jiazhuo; Shi, Cunzhen; Li, Hongwen; Song, Wenting; Huang, Shuo; Zhang, Jianxiang; Li, Wencai; Li, Zhaoming; Zhang, Mingzhi

Wu, Jiazhuo; Shi, Cunzhen; Li, Hongwen; Song, Wenting; Huang, Shuo; Zhang, Jianxiang; Li, Wencai; Li, Zhaoming; Zhang, Mingzhi.

Afiliação

Wu J; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Shi C; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Li H; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Song W; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Huang S; Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Zhang J; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Li W; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. liwencai@zzu.edu.cn.
Li Z; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. fcclizm@zzu.edu.cn.
Zhang M; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. mingzhi_zhang1@163.com.

BMC Med ; 21(1): 253, 2023 07 13.

Article em En | MEDLINE | ID: mdl-37442994

Assuntos

Antineoplásicos; Linfoma de Células T; Linfoma; Humanos; Cisplatino/farmacologia; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Linhagem Celular Tumoral; Antineoplásicos/farmacologia; Células Matadoras Naturais; RNA Mensageiro; Proteínas Proto-Oncogênicas/farmacologia; Proteínas Adaptadoras de Transdução de Sinal/farmacologia; Proteínas com Domínio LIM/farmacologia

Palavras-chave

DNA damage repair; LMO2; Natural killer/T cell lymphoma; PARP inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfoma de Células T / Linfoma / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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