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Immunomodulation Therapies for Atherosclerosis: The Past, the Present, and the Future.
Lecis, Dalgisio; Massaro, Gianluca; Benedetto, Daniela; Di Luozzo, Marco; Russo, Giulio; Mauriello, Alessandro; Federici, Massimo; Sangiorgi, Giuseppe Massimo.
Afiliação
  • Lecis D; Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
  • Massaro G; Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
  • Benedetto D; Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
  • Di Luozzo M; Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
  • Russo G; Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
  • Mauriello A; Department of Experimental Medicine, University "Tor Vergata", 00133 Rome, Italy.
  • Federici M; Department of Systemic Medicine, University "Tor Vergata", 00133 Rome, Italy.
  • Sangiorgi GM; Division of Cardiology, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.
Int J Mol Sci ; 24(13)2023 Jul 01.
Article em En | MEDLINE | ID: mdl-37446157
Atherosclerotic cardiovascular disease is the most common cause of morbidity and death worldwide. Recent studies have demonstrated that this chronic inflammatory disease of the arterial wall can be controlled through the modulation of immune system activity. Many patients with cardiovascular disease remain at elevated risk of recurrent events despite receiving current, state-of-the-art preventive medical treatment. Much of this residual risk is attributed to inflammation. Therefore, finding new treatment strategies for this category of patients became of common interest. This review will discuss the experimental and clinical data supporting the possibility of developing immune-based therapies for lowering cardiovascular risk, explicitly focusing on vaccination strategies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Imunomodulação Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Imunomodulação Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article