Insights into the Antioxidant/Antiradical Effects and In Vitro Intestinal Permeation of Oleocanthal and Its Metabolites Tyrosol and Oleocanthalic Acid.
Molecules
; 28(13)2023 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-37446813
ABSTRACT
(1) Background:
In recent years, numerous studies have highlighted the beneficial effects of extra virgin olive oil (EVOO) as an active ingredient against chronic diseases. The properties of EVOO are due to its peculiar composition, mainly to its rich content of polyphenols. In fact, polyphenols may contribute to counteract oxidative stress, which often accompanies chronic diseases. In this work, the antioxidant effects of high-value polyphenol oleocanthal (OC) and its main metabolites, tyrosol (Tyr) and oleocanthalic acid (OA), respectively, have been investigated along with their impact on cell viability. (2)Methods:
OC, Tyr, and OA have been evaluated regarding antiradical properties in term of scavenging capacity towards biologically relevant reactive species, including O2â-, HOCl, and ROOâ, as well as their antioxidant/antiradical capacity (FRAP, DPPHâ, ABTSâ+). Moreover, the ability to permeate the intestinal membrane was assessed by an intestinal co-culture model composed by Caco-2 and HT29-MTX cell lines. (3)Results:
The capacity of OC and Tyr as radical oxygen species (ROS) scavengers, particularly regarding HOCl and O2â-, was clearly demonstrated. Furthermore, the ability to permeate the intestinal co-culture model was plainly proved by the good permeations (>50%) achieved by all compounds. (4)Conclusions:
OC, OA, and Tyr revealed promising properties against oxidative diseases.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polifenóis
/
Antioxidantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article