Predictors of dopamine dysregulation syndrome in patients with early Parkinson's disease.
Neurol Sci
; 44(12): 4333-4342, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37452260
ABSTRACT
BACKGROUND:
Dopamine dysregulation syndrome (DDS) is a complication of Parkinson's disease (PD) that seriously affects the quality of life of PD patients. Currently, the risk factors for DDS are poorly known, and it is critical to identify them in the early stages of PD.OBJECTIVE:
To explore the incidence of and risk factors for DDS in patients with early PD.METHODS:
A retrospective cohort study was conducted on the general data, clinical features, and imaging data of patients with early PD in the PPMI database. Multivariate Cox regression analysis was performed to analyze the risk factors for the development of DDS in patients with early PD, and KaplanâMeier curves examined the frequency and predictors of incident DDS symptoms.RESULTS:
At baseline, 2.2% (n = 6) of patients with early PD developed DDS, and the cumulative incidence rates of DDS during the 5-year follow-up period were 2.8%, 6.4%, 10.8%, 15.5%, and 18.7%, respectively. In the multivariate Cox regression model controlling for age, sex, and drug use, hypersexuality (HR = 3.088; 95% CI 1.416~6.732; P = 0.005), compulsive eating (HR = 3.299; 95% CI 1.665~6.534; P = 0.001), compulsive shopping (HR = 3.899; 95% CI 1.769~8.593; P = 0.001), anxiety (HR = 4.018; 95% CI 2.136~7.599; P < 0.01), and lower Hoehn-Yahr (H-Y) stage (HR = 0.278; 95% CI 0.152~0.509; P < 0.01) were independent risk factors for DDS in patients with early PD. PD patients with DDS had lower DAT uptake values than those patients without DDS.CONCLUSION:
Early PD patients with hypersexuality, compulsive eating, compulsive shopping, anxiety, and lower H-Y stage were at increased risk for DDS. The occurrence of DDS may be related to the decrease in the average DAT uptake of the caudate and putamen.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Transtornos Disruptivos, de Controle do Impulso e da Conduta
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article