Amphiphilic peptide Mastoparan-B induces conformational changes within the AdeB efflux pump, down-regulates adeB gene expression, and restores antibiotic susceptibility in an MDR strain of Acinetobacter baumannii.

Shakibaie, Mohammad Reza; Modaresi, Farzan; Azizi, Omid; Tadjrobehkar, Omid; Ghaemi, Mohammad Mehdi

Shakibaie, Mohammad Reza; Modaresi, Farzan; Azizi, Omid; Tadjrobehkar, Omid; Ghaemi, Mohammad Mehdi.

Afiliação

Shakibaie MR; Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran.
Modaresi F; Gastroenterology Hepatology Research Center, Institute of Basic and Clinical Physiology, Kerman University of Medical Sciences, Kerman, Iran.
Azizi O; Department of Microbiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
Tadjrobehkar O; Department of Laboratory Sciences, and Health Sciences Research center, Torbat Heydariyeh University of Medical Sciences, Torbate Heydarieh, Iran.
Ghaemi MM; Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran.

Proteins ; 91(9): 1205-1221, 2023 09.

Article em En | MEDLINE | ID: mdl-37455426

Assuntos

Acinetobacter baumannii; Acinetobacter baumannii/genética; Acinetobacter baumannii/metabolismo; Proteínas de Bactérias/química; Antibacterianos/química; Proteínas de Membrana Transportadoras/química; Testes de Sensibilidade Microbiana; Simulação de Dinâmica Molecular; Expressão Gênica

Palavras-chave

AlphaFold2; Mastoparan-B; efflux pumps; molecular docking; protein modeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acinetobacter baumannii Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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