Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence.
Org Lett
; 25(29): 5406-5410, 2023 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-37458387
ABSTRACT
Herein, we report the transformation of aromatic acids to indole-fused seven- and eight-membered azaheterocycles. Two C-C bonds are formed via the cleavage of one C-C bond and two C-H bonds. The incorporation of indole moieties into bioactive pharmaceuticals and natural products to construct a medium-sized polyfused heterocycle demonstrates the synthetic utility of the protocol.
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MEDLINE
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En
Ano de publicação:
2023
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Article