LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus.
bioRxiv
; 2023 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-37461530
ABSTRACT
Adipocyte-derived leptin enters the brain to exert its anorexigenic action, yet its transport mechanism is poorly understood. Here we report that LRP1 (low-density lipoprotein receptor-related protein-1) mediates the transport of leptin across the blood-CSF barrier in Foxj1 expressing cells highly enriched at the choroid plexus (ChP), coupled with the short-form leptin receptor, and LRP1 deletion from ependymocytes and ChP cells leads to leptin resistance and hyperphagia, causing obesity. Thus, LRP1 in epithelial cells is a principal regulator of leptin transport in the brain.
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MEDLINE
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En
Ano de publicação:
2023
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Article