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Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo.
Neldeborg, Signe; Soerensen, Johannes Frasez; Møller, Charlotte Thornild; Bill, Marie; Gao, Zongliang; Bak, Rasmus O; Holm, Kasper; Sorensen, Boe; Nyegaard, Mette; Luo, Yonglun; Hokland, Peter; Stougaard, Magnus; Ludvigsen, Maja; Holm, Christian Kanstrup.
Afiliação
  • Neldeborg S; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Soerensen JF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Møller CT; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Bill M; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • Gao Z; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Bak RO; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • Holm K; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Sorensen B; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Nyegaard M; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Luo Y; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Hokland P; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
  • Stougaard M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Ludvigsen M; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
  • Holm CK; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Leukemia ; 37(9): 1792-1801, 2023 09.
Article em En | MEDLINE | ID: mdl-37464068
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Leucemia Mieloide Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Leucemia Mieloide Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article