Metallo-ß-lactamase SMB-1 evolves into a more efficient hydrolase under the selective pressure of meropenem.

Dong, Xiaoting; Liu, Wenli; Dong, Yuxuan; Wang, Kun; Li, Kewei; Bian, Liujiao

Dong, Xiaoting; Liu, Wenli; Dong, Yuxuan; Wang, Kun; Li, Kewei; Bian, Liujiao.

Afiliação

Dong X; College of Life Science, Northwest University, Xi'an 710069, China.
Liu W; College of Life Science, Northwest University, Xi'an 710069, China.
Dong Y; College of Life Science, Northwest University, Xi'an 710069, China.
Wang K; College of Life Science, Northwest University, Xi'an 710069, China.
Li K; College of Life Science, Northwest University, Xi'an 710069, China.
Bian L; College of Life Science, Northwest University, Xi'an 710069, China. Electronic address: bianliujiao@sohu.com.

J Inorg Biochem ; 247: 112323, 2023 10.

Article em En | MEDLINE | ID: mdl-37478781

Assuntos

Antibacterianos; beta-Lactamases; Meropeném; beta-Lactamases/metabolismo; Antibacterianos/química; Carbapenêmicos/química; Serratia marcescens/genética; Serratia marcescens/metabolismo

Palavras-chave

Antibiotic resistance; Conformational change; Distal mutation; Evolution; Metallo-ß-lactamase SMB-1; Mutational effects

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Antibacterianos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Antibacterianos Idioma: En Ano de publicação: 2023 Tipo de documento: Article