Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease.

Uliassi, Elisa; Bergamini, Christian; Rizzardi, Nicola; Naldi, Marina; Cores, Ángel; Bartolini, Manuela; Carlos Menéndez, J; Bolognesi, Maria Laura

Uliassi, Elisa; Bergamini, Christian; Rizzardi, Nicola; Naldi, Marina; Cores, Ángel; Bartolini, Manuela; Carlos Menéndez, J; Bolognesi, Maria Laura.

Afiliação

Uliassi E; Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy.
Bergamini C; Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy.
Rizzardi N; Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy.
Naldi M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy.
Cores Á; Department of Chemistry in Pharmaceutical Sciences, Organic and Medicinal Chemistry Unit, Faculty of Pharmacy, Universidad Complutense, 28040 Madrid, Spain.
Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy.
Carlos Menéndez J; Department of Chemistry in Pharmaceutical Sciences, Organic and Medicinal Chemistry Unit, Faculty of Pharmacy, Universidad Complutense, 28040 Madrid, Spain. Electronic address: josecm@farm.ucm.es.
Bolognesi ML; Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy. Electronic address: marialaura.bolognesi@unibo.it.

Bioorg Med Chem ; 91: 117419, 2023 08 15.

Article em En | MEDLINE | ID: mdl-37487339

Assuntos

Doença de Alzheimer; Neuroblastoma; Humanos; Tacrina/farmacologia; Tacrina/química; Doença de Alzheimer/tratamento farmacológico; Acetilcolinesterase; Ligantes; Inibidores da Colinesterase/farmacologia; Inibidores da Colinesterase/química; Antioxidantes/farmacologia; Peptídeos beta-Amiloides

Palavras-chave

Alzheimer's disease; Amyloid-ß; Cholinesterase enzymes; Multi-target-directed ligands; Polypharmacology; Quinolinetrione; Tacrine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Neuroblastoma Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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