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Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.
Luo, Renhe; Yan, Jielin; Oh, Jin Woo; Xi, Wang; Shigaki, Dustin; Wong, Wilfred; Cho, Hyein S; Murphy, Dylan; Cutler, Ronald; Rosen, Bess P; Pulecio, Julian; Yang, Dapeng; Glenn, Rachel A; Chen, Tingxu; Li, Qing V; Vierbuchen, Thomas; Sidoli, Simone; Apostolou, Effie; Huangfu, Danwei; Beer, Michael A.
Afiliação
  • Luo R; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Yan J; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Oh JW; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Xi W; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Shigaki D; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Wong W; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Cho HS; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
  • Murphy D; Computational & Systems Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Cutler R; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York City, NY, USA.
  • Rosen BP; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Pulecio J; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York City, NY, USA.
  • Yang D; Department of Medicine, Weill Cornell Medicine, New York City, NY, USA.
  • Glenn RA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Chen T; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Li QV; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York City, NY, USA.
  • Vierbuchen T; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Sidoli S; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Apostolou E; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
  • Huangfu D; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York City, NY, USA.
  • Beer MA; Developmental Biology Program, Sloan Kettering Institute, New York City, NY, USA.
Nat Genet ; 55(8): 1336-1346, 2023 08.
Article em En | MEDLINE | ID: mdl-37488417
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Elementos Facilitadores Genéticos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Elementos Facilitadores Genéticos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article