Non-compartmental and population pharmacokinetic analysis of dapsone in healthy NIGERIANS: A pilot study.
Br J Clin Pharmacol
; 89(11): 3454-3459, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-37489004
ABSTRACT
Dapsone is employed for both non-dermatological and dermatological indications but with non-existent population pharmacokinetics (popPK) data in Nigerians. This study was therefore designed to develop a popPK model in Nigerians. Non-compartmental analysis and nonlinear mixed effects modelling were utilized for data analysis. Eleven participants administered 50 mg dapsone tablet were included in the analysis. Derived pharmacokinetic parameters were Cmax = 1.16 ± 0.32 µg/mL, Tmax = 3.77 ± 2.40 h, and t1/2z = 30.23 ± 11.76 h. PopPK model parameter estimates with inter-individual variability were Tlag = 0.40 h (10.0%, fixed); ka = 1.78 h-1 (75.9%); V/F = 89.25 L (21.6%); and Cl/F = 1.32 Lh-1 (27.7%). Sex was significantly associated with Cl/F, and body weight with V/F. Best popPK model was one-compartment with lag time, and first-order absorption and elimination. Sex and body weight significantly influenced the clearance and distribution volume of dapsone respectively.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dapsona
/
Modelos Biológicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article