Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling.

Cong, Yi-Fan; Liu, Fu-Wang; Xu, Li; Song, Shuang-Shuang; Shen, Xu-Ri; Liu, Dong; Hou, Xue-Qin; Zhang, Han-Ting

Cong, Yi-Fan; Liu, Fu-Wang; Xu, Li; Song, Shuang-Shuang; Shen, Xu-Ri; Liu, Dong; Hou, Xue-Qin; Zhang, Han-Ting.

Afiliação

Cong YF; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Liu FW; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Xu L; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Song SS; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Shen XR; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Liu D; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Hou XQ; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, P.R. China.
Zhang HT; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong, P.R. China.

Int J Neuropsychopharmacol ; 26(9): 585-598, 2023 09 25.

Article em En | MEDLINE | ID: mdl-37490542

Assuntos

Doença de Alzheimer; Inibidores da Fosfodiesterase 4; Camundongos; Animais; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Precursor de Proteína beta-Amiloide/farmacologia; Rolipram/farmacologia; Camundongos Transgênicos; Inibidores da Fosfodiesterase 4/farmacologia; Doenças Neuroinflamatórias; Presenilina-1/metabolismo; Presenilina-1/farmacologia; Depressão/tratamento farmacológico; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Transtornos da Memória/tratamento farmacológico; Apoptose; Modelos Animais de Doenças

Palavras-chave

3×Tg-AD mice; Alzheimer disease; depression; phosphodiesterase-4; rolipram

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Fosfodiesterase 4 / Doença de Alzheimer Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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