Review of Envelope Statistics Models for Quantitative Ultrasound Imaging and Tissue Characterization.

The homodyned K-distribution and the K-distribution, viewed as a special case, as well as the Rayleigh and the Rice distributions, viewed as limit cases, are discussed in the context of quantitative ultrasound (QUS) imaging. The Nakagami distribution is presented as an approximation of the homodyned K-distribution. The main assumptions made are (1) the absence of log-compression or application of nonlinear filtering on the echo envelope of the radiofrequency signal and (2) the randomness and independence of the diffuse scatterers. We explain why other available models are less amenable to a physical interpretation of their parameters. We also present the main methods for the estimation of the statistical parameters of these distributions. We explain why we advocate the methods based on the X-statistics for the Rice and the Nakagami distributions and the K-distribution. The limitations of the proposed models are presented. Several new results are included in the discussion sections, with proofs in the appendix.