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A Radiomics Model Based on Synthetic MRI Acquisition for Predicting Neoadjuvant Systemic Treatment Response in Triple-Negative Breast Cancer.
Hwang, Ken-Pin; Elshafeey, Nabil A; Kotrotsou, Aikaterini; Chen, Huiqin; Son, Jong Bum; Boge, Medine; Mohamed, Rania M; Abdelhafez, Abeer H; Adrada, Beatriz E; Panthi, Bikash; Sun, Jia; Musall, Benjamin C; Zhang, Shu; Candelaria, Rosalind P; White, Jason B; Ravenberg, Elizabeth E; Tripathy, Debu; Yam, Clinton; Litton, Jennifer K; Huo, Lei; Thompson, Alastair M; Wei, Peng; Yang, Wei T; Pagel, Mark D; Ma, Jingfei; Rauch, Gaiane M.
Afiliação
  • Hwang KP; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Elshafeey NA; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Kotrotsou A; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Chen H; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Son JB; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Boge M; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Mohamed RM; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Abdelhafez AH; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Adrada BE; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Panthi B; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Sun J; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Musall BC; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Zhang S; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Candelaria RP; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • White JB; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Ravenberg EE; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Tripathy D; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Yam C; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Litton JK; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Huo L; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Thompson AM; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Wei P; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Yang WT; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Pagel MD; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Ma J; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
  • Rauch GM; From the Departments of Imaging Physics (K.P.H., A.K., J.B.S., B.P., B.C.M., J.M.), Breast Imaging (N.A.E., M.B., R.M.M., A.H.A., B.E.A., R.P.C., W.T.Y., G.M.R.), Biostatistics (H.C., J.S., P.W.), Cancer Systems Imaging (S.Z., M.D.P.), Moon Shots Operations (J.B.W.), Breast Medical Oncology (E.E.R.,
Radiol Imaging Cancer ; 5(4): e230009, 2023 07.
Article em En | MEDLINE | ID: mdl-37505106
ABSTRACT
Purpose To determine if a radiomics model based on quantitative maps acquired with synthetic MRI (SyMRI) is useful for predicting neoadjuvant systemic therapy (NAST) response in triple-negative breast cancer (TNBC). Materials and Methods In this prospective study, 181 women diagnosed with stage I-III TNBC were scanned with a SyMRI sequence at baseline and at midtreatment (after four cycles of NAST), producing T1, T2, and proton density (PD) maps. Histopathologic analysis at surgery was used to determine pathologic complete response (pCR) or non-pCR status. From three-dimensional tumor contours drawn on the three maps, 310 histogram and textural features were extracted, resulting in 930 features per scan. Radiomic features were compared between pCR and non-pCR groups by using Wilcoxon rank sum test. To build a multivariable predictive model, logistic regression with elastic net regularization and cross-validation was performed for texture feature selection using 119 participants (median age, 52 years [range, 26-77 years]). An independent testing cohort of 62 participants (median age, 48 years [range, 23-74 years]) was used to evaluate and compare the models by area under the receiver operating characteristic curve (AUC). Results Univariable analysis identified 15 T1, 10 T2, and 12 PD radiomic features at midtreatment that predicted pCR with an AUC greater than 0.70 in both the training and testing cohorts. Multivariable radiomics models of maps acquired at midtreatment demonstrated superior performance over those acquired at baseline, achieving AUCs as high as 0.78 and 0.72 in the training and testing cohorts, respectively. Conclusion SyMRI-based radiomic features acquired at midtreatment are potentially useful for identifying early NAST responders in TNBC. Keywords MR Imaging, Breast, Outcomes Analysis ClinicalTrials.gov registration no. NCT02276443 Supplemental material is available for this article. © RSNA, 2023 See also the commentary by Houser and Rapelyea in this issue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article