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Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy.
Scimeca, Manuel; Rovella, Valentina; Palumbo, Valeria; Scioli, Maria Paola; Bonfiglio, Rita; Melino, Gerry; Piacentini, Mauro; Frati, Luigi; Agostini, Massimiliano; Candi, Eleonora; Mauriello, Alessandro.
Afiliação
  • Scimeca M; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Rovella V; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Palumbo V; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Scioli MP; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Bonfiglio R; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Melino G; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Piacentini M; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Frati L; Institute Pasteur Italy-Cenci Bolognetti Foundation, Via Regina Elena 291, 00161 Rome, Italy.
  • Agostini M; IRCCS Neuromed S.p.A., Via Atinense 18, 86077 Pozzilli, Italy.
  • Candi E; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Mauriello A; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy.
Cancers (Basel) ; 15(14)2023 Jul 15.
Article em En | MEDLINE | ID: mdl-37509299
Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. The limited effectiveness of conventional therapies has prompted the search for new approaches to target this disease. Recent evidence suggests that distinct programmed cell death mechanisms, namely, apoptosis, ferroptosis, pyroptosis and necroptosis, play a critical role in the development and progression of cholangiocarcinoma. This review aims to summarize the current knowledge on the role of programmed cell death in cholangiocarcinoma and its potential implications for the development of novel therapies. Several studies have shown that the dysregulation of apoptotic signaling pathways contributes to cholangiocarcinoma tumorigenesis and resistance to treatment. Similarly, ferroptosis, pyroptosis and necroptosis, which are pro-inflammatory forms of cell death, have been implicated in promoting immune cell recruitment and activation, thus enhancing the antitumor immune response. Moreover, recent studies have suggested that targeting cell death pathways could sensitize cholangiocarcinoma cells to chemotherapy and immunotherapy. In conclusion, programmed cell death represents a relevant molecular mechanism of pathogenesis in cholangiocarcinoma, and further research is needed to fully elucidate the underlying details and possibly identify therapeutic strategies.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article