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Clinical trial participation among underserved communities: Insights from the Louisiana Community Engagement Alliance.
Craig, Leslie S; Sarpong, Daniel F; Peacock, Erin M; Theall, Katherine P; Williams, LaKeisha; Al-Dahir, Sara; Davis, Terry C; Arnold, Connie L; Williams, Allie; Fields, Tynesia; Wilson, Michelle; Krousel-Wood, Marie.
Afiliação
  • Craig LS; Tulane University, School of Medicine, New Orleans, LA, USA.
  • Sarpong DF; Xavier University of Louisiana, College of Pharmacy, New Orleans, LA, USA; Yale School of Medicine, General Internal Medicine, Office of Health Equity Research.
  • Peacock EM; Tulane University, School of Medicine, New Orleans, LA, USA.
  • Theall KP; Tulane University, School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Williams L; Xavier University of Louisiana, College of Pharmacy, New Orleans, LA, USA.
  • Al-Dahir S; Xavier University of Louisiana, College of Pharmacy, New Orleans, LA, USA.
  • Davis TC; Louisiana State University Health Shreveport, Shreveport, LA, USA.
  • Arnold CL; Louisiana State University Health Shreveport, Shreveport, LA, USA.
  • Williams A; Tulane University, School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Fields T; Xavier University of Louisiana, College of Pharmacy, New Orleans, LA, USA.
  • Wilson M; Tulane University, School of Medicine, New Orleans, LA, USA.
  • Krousel-Wood M; Tulane University, School of Medicine, New Orleans, LA, USA; Tulane University, School of Public Health and Tropical Medicine, New Orleans, LA, USA. Electronic address: mawood@tulane.edu.
Am J Med Sci ; 366(4): 254-262, 2023 10.
Article em En | MEDLINE | ID: mdl-37517691
BACKGROUND: Diverse, equitable and inclusive participation in clinical research is needed to ensure evidence-based clinical practice and lessen disparities in health outcomes. Yet, clinical trial participation remains critically low in minoritized communities, particularly among Blacks. The Louisiana Community Engagement Alliance against COVID-19 Disparities (LA-CEAL) was launched in response to the disproportionate impact of COVID-19 on Black Louisianans to understand community barriers and preferences and increase inclusive participation in research. This study aims to understand perceptions regarding COVID-19 trial participation among underrepresented Louisianans. METHODS: A rapid assessment integrating cross-sectional, surveys among federally qualified health center (FQHC) patients and community residents, and focus group discussions (FGDs) from community representatives was conducted in 2020-2021. Factors and perceptions underlying trial participation were identified using logistic regression models and thematic analyses, respectively. RESULTS: Quantitative findings (FQHC: N=908, mean age=46.6 years, 66.4% Black; community: N=504, mean age=54.2 years, 93.7% Black) indicated that 0.9% and 3.6%, respectively, ever participated in a COVID-19 trial. Doctors/Healthcare providers were most trusted (FQHC=55.1%; community=59.3%) sources of information about trials. Advancing age was associated with increased odds of being very willing to participate (ORFQHC=1.03, 95% CI 1.02-1.05; ORCommunity=1.02, 95% CI 1.00-1.04). Qualitative data (6 FGDs, 29 attendees) revealed limited awareness, experimentation/exploitation-based fears, and minimal racial/ethnic representation among trialists as barriers to participation. CONCLUSION: COVID-19 trial participation rates were low in our sample. Altruism was a key facilitator to participation; fear, mistrust, and low awareness were predominant barriers. Community-centered approaches, engaging informed providers and trusted community members, may facilitate inclusive trial participation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Humans / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Limite: Humans / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article