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Mortality and cardiovascular risk in vasculitis ANCA. Importance of hypertension and renal function. Experience from southern Spain.
Martin-Gómez, M A; Rodríguez Torres, A; Espinosa Hernández, M; Lopez Mendoza, M; Sabio Sánchez, J M; Martin Armada, M; Martin Suarez, I; Callejas Rubio, J L; Castilla Castellano, M M; Anglada Pintado, J C; Barnosi Marín, A C; Martinez Esteban, M D; Castilla Guerra, L; De Ramón Garrido, E.
Afiliação
  • Martin-Gómez MA; Nephrology Poniente Hospital, El Ejido, Almería, Spain. Electronic address: doritamg@gmail.com.
  • Rodríguez Torres A; Nephrology Pediatrician Torrecardenas Hospital, Almería, Spain.
  • Espinosa Hernández M; Nephrology Reina Sofía Hospital, Córdoba, Spain.
  • Lopez Mendoza M; Nephrology Virgen del Rocío Hospital, Sevilla, Spain.
  • Sabio Sánchez JM; Internal Medicine Autoimmune Unit, Virgen de las Nieves Hospital, Granada, Spain.
  • Martin Armada M; Internal Medicine, Jaén Hospital Complex, Jaén, Spain.
  • Martin Suarez I; Internal Medicine, Juan Ramón Jiménez Hospital, Huelva, Spain.
  • Callejas Rubio JL; Internal Medicine, San Cecilio Clinic Hospital, Granada, Spain.
  • Castilla Castellano MM; Nephrology Costa del Sol Hospital, Marbella, Málaga, Spain.
  • Anglada Pintado JC; Internal Medicine, University Hospital of Jerez, Jerez, Cádiz, Spain.
  • Barnosi Marín AC; Internal Medicine, Torrecárdenas Hospital, Almería, Spain.
  • Martinez Esteban MD; Nephrology Universitary Regional Hospital of Málaga, Málaga, Spain.
  • Castilla Guerra L; Internal Medicine, Virgen de Macarena Hospital, Sevilla, Spain.
  • De Ramón Garrido E; Internal Medicine, Andalussian Society of Autoimmune Diseases (AADEA), Spain.
Hipertens Riesgo Vasc ; 41(1): 5-16, 2024.
Article em En | MEDLINE | ID: mdl-37517951
BACKGROUND: Cardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV). OBJECTIVES: To evaluate the mortality and it's causes and CVD and its vascular risk factors (VRFs) in AAV patients in Andalusia. METHODS: A multicenter cohort of 220 AAV patients followed-up from 1979 until June 2020 was studied in Andalussia, south of Spain. The information, including socio-demographic and clinical data was recorded retrospectively through chart review. Data was analysed using Chi2, ANOVA and Cox proportional hazards regresion as uni and multivariate test with a 95% confidence interval (CI). RESULTS: During a mean ± standard deviation follow-up of 96.79 ± 75.83 months, 51 patients died and 30 presented at least one CVE. Independent prognostic factors of mortality were age (HR 1.083, p=0.001) and baseline creatinine (HR 4.41, p=0.01). Independent prognostic factors of CVE were age [hazard ratio (HR) 1.042, p=0.005] and the presence of hypertension (HTN) six months after diagnosis (HR 4.641, p=0.01). HTN, diabetes and renal failure, all of these important VRFs, are more prevalent in AAV patients than it is described in matched general population. CONCLUSIONS: Age and baseline renal function, but not CVEs, are predictors of mortality and age and early HTN are independent predictors for having a CVE. CVD screening in AAV patients is demanded.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos / Hipertensão Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos / Hipertensão Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article