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Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration.
Mi, Bobin; Xiong, Yuan; Zha, Kangkang; Cao, Faqi; Zhou, Wu; Abbaszadeh, Samin; Ouyang, Lizhi; Liao, Yuheng; Hu, Weixian; Dai, Guandong; Zhao, Zhiming; Feng, Qian; Shahbazi, Mohammad-Ali; Liu, Guohui.
Afiliação
  • Mi B; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
  • Xiong Y; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • Zha K; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
  • Cao F; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • Zhou W; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
  • Abbaszadeh S; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • Ouyang L; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
  • Liao Y; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • Hu W; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
  • Dai G; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • Zhao Z; Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Feng Q; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
  • Shahbazi MA; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
  • Liu G; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. liuguohui@hust.edu.cn.
Biomater Sci ; 11(18): 6035-6059, 2023 Sep 12.
Article em En | MEDLINE | ID: mdl-37522328
Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Fraturas Ósseas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Fraturas Ósseas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article