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Synthesis of Polysubstituted Pyrimidines through Palladium-Catalyzed Isocyanide Insertion to 2H-Azirines.
Saeifard, Leyla; Amiri, Kamran; Rominger, Frank; Müller, Thomas J J; Balalaie, Saeed.
Afiliação
  • Saeifard L; Peptide Chemistry Research Institute, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.
  • Amiri K; Peptide Chemistry Research Institute, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.
  • Rominger F; Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 271, D-69120 Heidelberg, Germany.
  • Müller TJJ; Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
  • Balalaie S; Peptide Chemistry Research Institute, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.
J Org Chem ; 88(17): 12519-12525, 2023 Sep 01.
Article em En | MEDLINE | ID: mdl-37524078
ABSTRACT
The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2H-azirine provides various tetrasubstituted pyrimidines via one C-C bond and two C-N bond formations with satisfactory yields. The title compounds are obtained with good functional group tolerance, high atom economy, and broad substrate scopes.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article