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[Assembly and Disassembly of the Nuclear Pore Complex: A View from the Structural Side].
Orlova, A V; Georgieva, S G; Kopytova, D V.
Afiliação
  • Orlova AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
  • Georgieva SG; chipushka@gmail.com.
  • Kopytova DV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Mol Biol (Mosk) ; 57(4): 573-586, 2023.
Article em Ru | MEDLINE | ID: mdl-37528778
Nucleocytoplasmic exchange in the cell occurs through the nuclear pore complexes (NPCs). NPCs are large multiprotein complexes with octagonal symmetry about their axis and imperfect mirror symmetry about a plane parallel with the nuclear envelop (NE). NPC fuses the inner and outer nuclear membranes and opens up a channel between nucleus and cytoplasm. NPC is built of nucleoporins. Each nucleoporin occurs in at least eight copies per NPC. Inside the NPC a permeability barrier forms by which NPCs can provide fast and selectable transport of molecules from one side of the nuclear membrane to the other. NPC architecture is based on hierarchical principle of organization. Nucleoporins are integrated into complexes that oligomerizes into bigger octomeric high-order structures. These structures are the main components of NPCs. In the first part of this work, the main attention is paid to NPC structure and nucleoporin properties. The second part is dedicated to mechanisms of NPC assembly and disassembly at different stages of the cell cycle.
Assuntos
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poro Nuclear / Complexo de Proteínas Formadoras de Poros Nucleares Idioma: Ru Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poro Nuclear / Complexo de Proteínas Formadoras de Poros Nucleares Idioma: Ru Ano de publicação: 2023 Tipo de documento: Article