Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice.
Front Endocrinol (Lausanne)
; 14: 1200391, 2023.
Article
em En
| MEDLINE
| ID: mdl-37534214
ABSTRACT
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes pathogenesis. However, how p-cresol affects gut hormones is unclear. Here, we expose immortalized GLUTag cells to increasing concentrations of p-cresol and found that p-cresol inhibited Gcg expression and reduced glucagon-like peptide-1 (GLP-1) secretion in vitro. In mice, administration of p-cresol in the drinking water for 2 weeks reduced the transcript levels of Gcg and other gut hormones in the colon; however, it did not affect either fasting or glucose-induced plasma GLP-1 levels. Furthermore, it did not affect glucose tolerance but promoted faster small intestinal transit in mice. Overall, our data suggest that microbial metabolite p-cresol suppresses transcript levels of gut hormones and regulates small intestinal transit in mice.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cresóis
/
Peptídeo 1 Semelhante ao Glucagon
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article