Association of adverse effects with high serum posaconazole concentrations.

Jensen, Kelsey; Saleh, Omar Abu; Chesdachai, Supavit; Jannetto, Paul J; Mara, Kristin C; Yetmar, Zachary A; Rivera, Christina G

Jensen, Kelsey; Saleh, Omar Abu; Chesdachai, Supavit; Jannetto, Paul J; Mara, Kristin C; Yetmar, Zachary A; Rivera, Christina G.

Afiliação

Jensen K; Department of Pharmacy, Mayo Clinic Health System, Austin, MN, USA.
Saleh OA; Division of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Chesdachai S; Division of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Jannetto PJ; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA.
Mara KC; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Yetmar ZA; Division of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Rivera CG; Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.

Med Mycol ; 61(8)2023 Aug 02.

Article em En | MEDLINE | ID: mdl-37537152

Drug level monitoring is commonly used to evaluate appropriate dosing and effectiveness of posaconazole, a medication used to treat fungal infections. Patients with high levels commonly had side effects. Posaconazole monitoring should be completed, and doses reduced when levels are high.

Assuntos

Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos; Infecções Fúngicas Invasivas; Animais; Antifúngicos/efeitos adversos; Infecções Fúngicas Invasivas/tratamento farmacológico; Infecções Fúngicas Invasivas/prevenção & controle; Infecções Fúngicas Invasivas/veterinária; Estudos Retrospectivos; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/veterinária

Palavras-chave

drug monitoring; posaconazole; posaconazole toxicity; supratherapeutic posaconazole; triazoles

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Infecções Fúngicas Invasivas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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