O-GlcNAcylation of Raptor transduces glucose signals to mTORC1.

Xu, Chenchen; Pan, Xiaoqing; Wang, Dong; Guan, Yuanyuan; Yang, Wenyu; Chen, Xing; Liu, Ying

Xu, Chenchen; Pan, Xiaoqing; Wang, Dong; Guan, Yuanyuan; Yang, Wenyu; Chen, Xing; Liu, Ying.

Afiliação

Xu C; State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Pan X; College of Chemistry and Molecular Engineering, Peking University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Wang D; State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Guan Y; State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.
Yang W; Yuan Pei College, Peking University, Beijing 100871, China.
Chen X; College of Chemistry and Molecular Engineering, Peking University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Beijing National Laboratory for Molecular Sciences, Peking University, Beijing 100871, China; Synthetic and Functional Biomolecules C
Liu Y; State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Beijing Advanced Innovation Cente

Mol Cell ; 83(16): 3027-3040.e11, 2023 08 17.

Article em En | MEDLINE | ID: mdl-37541260

Assuntos

Proteínas Adaptadoras de Transdução de Sinal; Complexos Multiproteicos; Humanos; Alvo Mecanístico do Complexo 1 de Rapamicina/genética; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Células HEK293; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Complexos Multiproteicos/metabolismo; Proteína Regulatória Associada a mTOR/genética; Proteína Regulatória Associada a mTOR/metabolismo; Fosforilação

Palavras-chave

O-GlcNAcylation; Raptor; glucose sensing; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexos Multiproteicos / Proteínas Adaptadoras de Transdução de Sinal Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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