Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder.

Leung, Beatrice K; Merlin, Sam; Walker, Adam K; Lawther, Adam J; Paxinos, George; Eapen, Valsamma; Clarke, Raymond; Balleine, Bernard W; Furlong, Teri M

Leung, Beatrice K; Merlin, Sam; Walker, Adam K; Lawther, Adam J; Paxinos, George; Eapen, Valsamma; Clarke, Raymond; Balleine, Bernard W; Furlong, Teri M.

Afiliação

Leung BK; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.
Merlin S; School of Science, Western Sydney University, Campbelltown, Sydney, NSW, Australia.
Walker AK; Laboratory of ImmunoPsychiatry, Neuroscience Research Australia, Randwick, NSW, Australia; Discipline of Psychiatry and Mental Health, University of New South Wales, NSW, Australia.
Lawther AJ; Laboratory of ImmunoPsychiatry, Neuroscience Research Australia, Randwick, NSW, Australia.
Paxinos G; Neuroscience Research Australia, Randwick, NSW, Australia; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia.
Eapen V; Discipline of Psychiatry and Mental Health, University of New South Wales, NSW, Australia; Mental Health Research Unit, South Western Sydney Local Health District, Liverpool, Australia.
Clarke R; Ingham Institute, Discipline of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Balleine BW; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.
Furlong TM; Neuroscience Research Australia, Randwick, NSW, Australia; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia. Electronic address: t.furlong@unsw.edu.au.

Behav Brain Res ; 452: 114610, 2023 08 24.

Article em En | MEDLINE | ID: mdl-37541448

Assuntos

Transtorno do Espectro Autista; Tiques; Síndrome de Tourette; Animais; Masculino; Camundongos; Transtorno do Espectro Autista/genética; Objetivos; Neurônios/metabolismo; Síndrome de Tourette/genética; Síndrome de Tourette/metabolismo

Palavras-chave

Autism spectrum disorder; Goal-directed learning; Habitual behavior; Instrumental learning; Mouse model; Pavlovian-to-instrumental transfer; Tourette's syndrome; Translational models

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Tourette / Tiques / Transtorno do Espectro Autista Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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