CPT2-mediated fatty acid oxidation inhibits tumorigenesis and enhances sorafenib sensitivity via the ROS/PPARÎ³/NF-&#954;B pathway in clear cell renal cell carcinoma.

Zeng, Kai; Li, Qinyu; Song, Guoda; Chen, Bingliang; Luo, Min; Miao, Jianping; Liu, Bo

CPT2-mediated fatty acid oxidation inhibits tumorigenesis and enhances sorafenib sensitivity via the ROS/PPARÎ³/NF-κB pathway in clear cell renal cell carcinoma.

Zeng, Kai; Li, Qinyu; Song, Guoda; Chen, Bingliang; Luo, Min; Miao, Jianping; Liu, Bo.

Afiliação

Zeng K; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; Department of Urology, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, Xinjiang, China.
Li Q; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Song G; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Chen B; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Luo M; Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: ZN003597@whu.edu.cn.
Miao J; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address: miaojianping888@hotmail.com.
Liu B; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address: boliu888@hotmail.com.

Cell Signal ; 110: 110838, 2023 10.

Article em En | MEDLINE | ID: mdl-37541641

Assuntos

Carcinoma de Células Renais; Carcinoma; Neoplasias Renais; Humanos; Carcinoma de Células Renais/tratamento farmacológico; Carcinoma de Células Renais/genética; Sorafenibe/farmacologia; NF-kappa B/metabolismo; PPAR gama/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Carnitina O-Palmitoiltransferase/genética; Carnitina O-Palmitoiltransferase/metabolismo; Linhagem Celular Tumoral; Neoplasias Renais/tratamento farmacológico; Neoplasias Renais/genética; Carcinogênese/genética; Transformação Celular Neoplásica/genética; Ácidos Graxos; Proliferação de Células/genética; Regulação Neoplásica da Expressão Gênica

Palavras-chave

CPT2; Clear cell renal cell carcinoma; Fatty acid oxidation; ROS; Sorafenib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Carcinoma de Células Renais / Neoplasias Renais Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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