Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation.

Rees, Martin; Nikoopour, Roksana; Alexandrovich, Alexander; Pfuhl, Mark; Lopes, Luis R; Akhtar, Mohammed M; Syrris, Petros; Elliott, Perry; Carr-White, Gerry; Gautel, Mathias

Rees, Martin; Nikoopour, Roksana; Alexandrovich, Alexander; Pfuhl, Mark; Lopes, Luis R; Akhtar, Mohammed M; Syrris, Petros; Elliott, Perry; Carr-White, Gerry; Gautel, Mathias.

Afiliação

Rees M; Randall Centre for Cell and Molecular Biophysics, King's College London BHF Centre of Research Excellence, United Kingdom. Electronic address: martin.rees@kcl.ac.uk.
Nikoopour R; Randall Centre for Cell and Molecular Biophysics, King's College London BHF Centre of Research Excellence, United Kingdom.
Alexandrovich A; Randall Centre for Cell and Molecular Biophysics, King's College London BHF Centre of Research Excellence, United Kingdom.
Pfuhl M; Randall Centre for Cell and Molecular Biophysics, King's College London BHF Centre of Research Excellence, United Kingdom; School of Cardiovascular Sciences and Medicine, King's College London, United Kingdom.
Lopes LR; Institute of Cardiovascular Science, University College London, United Kingdom; Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
Akhtar MM; Institute of Cardiovascular Science, University College London, United Kingdom.
Syrris P; Institute of Cardiovascular Science, University College London, United Kingdom.
Elliott P; Institute of Cardiovascular Science, University College London, United Kingdom; Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
Carr-White G; Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; School of Biomedical Engineering and Imaging Sciences, Rayne Institute, King's College London, St Thomas' Hospital, London, United Kingdom.
Gautel M; Randall Centre for Cell and Molecular Biophysics, King's College London BHF Centre of Research Excellence, United Kingdom. Electronic address: mathias.gautel@kcl.ac.uk.

J Struct Biol ; 215(3): 108009, 2023 09.

Article em En | MEDLINE | ID: mdl-37549721

Assuntos

Proteínas Musculares; Sarcômeros; Humanos; Conectina/genética; Proteínas Musculares/química; Proteínas Musculares/genética; Proteínas Musculares/metabolismo; Domínio de Fibronectina Tipo III; Músculo Esquelético

Palavras-chave

Fibronectin type III; Muscle; Myopathy; Titin; X-ray crystallography

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcômeros / Proteínas Musculares Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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