Cytokine Inhibitors Upregulate Extracellular Matrix Anabolism of Human Intervertebral Discs under Alginate Beads and Alginate-Embedded Explant Cultures.

Kakutani, Kenichiro; Yurube, Takashi; An, Howard S; Doita, Minoru; Masuda, Koichi

Kakutani, Kenichiro; Yurube, Takashi; An, Howard S; Doita, Minoru; Masuda, Koichi.

Afiliação

Kakutani K; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Yurube T; Department of Orthopaedic Surgery, Rush University Medical Center, Orthopaedic Building, Suite 300, 1611 W Harrison Street, Chicago, IL 60612, USA.
An HS; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Doita M; Department of Orthopaedic Surgery, Rush University Medical Center, Orthopaedic Building, Suite 300, 1611 W Harrison Street, Chicago, IL 60612, USA.
Masuda K; Department of Orthopedic Surgery, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Showa-gun, Iwate 028-3895, Japan.

Int J Mol Sci ; 24(15)2023 Aug 02.

Article em En | MEDLINE | ID: mdl-37569715

Assuntos

Degeneração do Disco Intervertebral; Disco Intervertebral; Humanos; Citocinas/metabolismo; Degeneração do Disco Intervertebral/metabolismo; Proteína Antagonista do Receptor de Interleucina 1/farmacologia; Proteína Antagonista do Receptor de Interleucina 1/metabolismo; Disco Intervertebral/metabolismo; Matriz Extracelular/metabolismo; Proteoglicanas/metabolismo; Receptores de Interleucina-1/metabolismo; Colágeno/metabolismo

Palavras-chave

autocrine; cytokine; intervertebral disc metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração do Disco Intervertebral / Disco Intervertebral Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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