Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti.
Molecules
; 28(15)2023 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-37570609
ABSTRACT
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1-15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
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Base de dados:
MEDLINE
Assunto principal:
Vinca
/
Alcaloides
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Antineoplásicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article