A phase II antiemetic combination (COMD) for cisplatin-induced nausea and vomiting.
Cancer Chemother Pharmacol
; 18(1): 88-9, 1986.
Article
em En
| MEDLINE
| ID: mdl-3757163
ABSTRACT
Thirteen patients resistant to high-dose metoclopramide (greater than or equal to 5 emetic episodes in 24 h following chemotherapy) were treated in the subsequent course of CDDP chemotherapy with COMD (chlorpromazine, orphenadrine, metoclopramide, dexamethasone). A statistically significant reduction in the number of vomiting episodes was obtained, and 69% of patients showed a better acceptance of CDDP treatment. Subsequently, the same antiemetic combination was administered to 31 untreated patients receiving CDDP alone for the first time 67.7% obtained complete protection from vomiting with minimal toxicity. According to our experience, COMD is an efficacious and well-tolerated antiemetic combination in cisplatin-treated patients; however, further studies with larger numbers of patients are required to confirm these preliminary results.
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Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Orfenadrina
/
Clorpromazina
/
Metoclopramida
/
Antieméticos
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article