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Pregnancy Outcomes in Women Screened for Tuberculosis Infection in Swedish Antenatal Care.
Walles, John; Winqvist, Niclas; Hansson, Stefan R; Sturegård, Erik; Baqir, Haitham; Westman, Anna; Kjerstadius, Torbjörn; Schön, Thomas; Björkman, Per.
Afiliação
  • Walles J; Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.
  • Winqvist N; Department of Infectious Diseases, Central Hospital, Kristianstad, Sweden.
  • Hansson SR; Department of Clinical Microbiology, Infection Control and Prevention, Skåne University Hospital Lund, Lund, Sweden.
  • Sturegård E; Skåne Regional Office for Infectious Disease Control and Prevention, Malmö, Sweden.
  • Baqir H; Division of Obstetrics and Gynaecology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
  • Westman A; Skåne University Hospital, Lund, Sweden.
  • Kjerstadius T; Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.
  • Schön T; Department of Clinical Microbiology, Infection Control and Prevention, Skåne University Hospital Lund, Lund, Sweden.
  • Björkman P; Department of Clinical Microbiology, Linköping University Hospital, Linköping, Sweden.
Clin Infect Dis ; 78(1): 125-132, 2024 01 25.
Article em En | MEDLINE | ID: mdl-37572363
ABSTRACT

BACKGROUND:

Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden.

METHODS:

Women with history of immigration from TB-endemic countries were eligible for inclusion if national identification numbers and available QuantiFERON results obtained during pregnancy from 2014 to 2018 were available. QuantiFERON results were linked to data on maternal characteristics and pregnancy outcomes from the national Pregnancy and Patient Registers. TBI was defined as nil-corrected QuantiFERON result ≥0.35 IU/mL, in the absence of TB disease. Pregnancies in women with TB disease or human immunodeficiency virus were excluded, as were multiplex pregnancies, pregnancies resulting in miscarriage, and pregnancies occurring >10 years after immigration. Odds of defined adverse pregnancy outcomes were compared by maternal TBI status using mixed effects logistic regression with adjustment for maternal age and region of origin.

RESULTS:

In total, 7408 women with 12 443 pregnancies were included. In multivariable analysis, stillbirth (adjusted odds ratio [AOR], 1.90; 95% confidence interval [CI], 1.13-3.21; P = .016), severe preeclampsia (AOR, 1.62; 95% CI, 1.03-2.56; P = .036), low birthweight (<2500 g; AOR, 1.38; 95% CI, 1.01-1.88; P = .041), and emergency cesarean section (AOR, 1.28; 95% CI, 1.02-1.63; P = .033) were significantly associated with TBI.

CONCLUSIONS:

Among immigrant women seeking antenatal care in Sweden, TBI was independently associated with adverse pregnancy outcomes. Further studies are needed to corroborate these findings and to explore mechanisms involved.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Tuberculose Latente Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Tuberculose Latente Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article