Effect of flavonoids on the destabilization of &#945;-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study.

Jahan, Ishrat; Ahmad, Aziz; Deep, Shashank

Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study.

Jahan, Ishrat; Ahmad, Aziz; Deep, Shashank.

Afiliação

Jahan I; Department of Chemistry, Indian Institute of Technology Delhi, Delhi 110016, India.
Ahmad A; Department of Chemistry, Indian Institute of Technology Delhi, Delhi 110016, India.
Deep S; Department of Chemistry, Indian Institute of Technology Delhi, Delhi 110016, India. Electronic address: sdeep@chemistry.iitd.ac.in.

Biochim Biophys Acta Proteins Proteom ; 1871(6): 140951, 2023 11 01.

Article em En | MEDLINE | ID: mdl-37574034

Assuntos

Doenças Neurodegenerativas; Doença de Parkinson; Humanos; alfa-Sinucleína/química; Simulação de Dinâmica Molecular; Flavonoides

Palavras-chave

AFM; Aggregation prone state (APS); Galangin; Kaempferol; Morin; Myricetin; Quercetin; Umbrella sampling; α-Syn

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Doenças Neurodegenerativas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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