Glucarpidase (carboxypeptidase G2): Biotechnological production, clinical application as a methotrexate antidote, and placement in targeted cancer therapy.

Moradbeygi, Fatemeh; Ghasemi, Younes; Farmani, Ahmad Reza; Hemmati, Shiva

Moradbeygi, Fatemeh; Ghasemi, Younes; Farmani, Ahmad Reza; Hemmati, Shiva.

Afiliação

Moradbeygi F; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Ghasemi Y; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Farmani AR; Tissue Engineering Department, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Hemmati S; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: hemmatish@sums.ac.ir.

Biomed Pharmacother ; 166: 115292, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37579696

Assuntos

Neoplasias; Pró-Fármacos; Humanos; Metotrexato/uso terapêutico; gama-Glutamil Hidrolase/genética; gama-Glutamil Hidrolase/uso terapêutico; Antídotos; Anticorpos/uso terapêutico; Polímeros/uso terapêutico

Palavras-chave

Antibody; CAR-T cell; Cell-penetrating peptides; Drug delivery system; Personalized medicine; Targeted cancer therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article