Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats.

Wang, Xue; Shi, Ya-Jin; Niu, Ting-Yuan; Chen, Ting-Ting; Li, Han-Bing; Wu, Su-Hui; Li, Gen-Lin

Wang, Xue; Shi, Ya-Jin; Niu, Ting-Yuan; Chen, Ting-Ting; Li, Han-Bing; Wu, Su-Hui; Li, Gen-Lin.

Afiliação

Wang X; Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Shi YJ; Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Niu TY; Medical College, Henan University of Chinese Medicine, Zheng-Zhou 450046, China.
Chen TT; Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Li HB; Medical College, Henan University of Chinese Medicine, Zheng-Zhou 450046, China.
Wu SH; Medical College, Henan University of Chinese Medicine, Zheng-Zhou 450046, China. Electronic address: wusuhui@hactcm.edu.cn.
Li GL; Medical College, Henan University of Chinese Medicine, Zheng-Zhou 450046, China. Electronic address: lgl88@hactcm.edu.cn.

Neurosci Lett ; 814: 137439, 2023 09 25.

Article em En | MEDLINE | ID: mdl-37579868

Assuntos

Demência Vascular; Fármacos Neuroprotetores; Ratos; Masculino; Animais; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Fármacos Neuroprotetores/metabolismo; Demência Vascular/metabolismo; Microglia/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Ratos Sprague-Dawley; Piroptose; Ácido Aspártico Endopeptidases/metabolismo

Palavras-chave

Beta-amyloid; Microglia; NLRP3 inflammasome; Protopanaxadiol; Tau; Vascular dementia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Vascular / Fármacos Neuroprotetores Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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