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Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction.
Liu, Yuchang; Wang, Minrui; Yu, Yang; Li, Chunhong; Zhang, Chunxiang.
Afiliação
  • Liu Y; Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.
  • Wang M; School of Basic Medical Science, Southwest Medical University, Luzhou, 646000, Sichuan, China.
  • Yu Y; Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
  • Li C; Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China. lispringhong@126.com.
  • Zhang C; Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. zhangchunxiangKZL@163.com.
Cell Commun Signal ; 21(1): 202, 2023 08 14.
Article em En | MEDLINE | ID: mdl-37580705
Acute myocardial infarction has long been the leading cause of death in coronary heart disease, which is characterized by irreversible cardiomyocyte death and restricted blood supply. Conventional reperfusion therapy can further aggravate myocardial injury. Stem cell therapy, especially with mesenchymal stem cells (MSCs), has emerged as a promising approach to promote cardiac repair and improve cardiac function. MSCs may induce these effects by secreting exosomes containing therapeutically active RNA, proteins and lipids. Notably, normal cardiac function depends on intracardiac paracrine signaling via exosomes, and exosomes secreted by cardiac cells can partially reflect changes in the heart during disease, so analyzing these vesicles may provide valuable insights into the pathology of myocardial infarction as well as guide the development of new treatments. The present review examines how exosomes produced by MSCs and cardiac cells may influence injury after myocardial infarction and serve as therapies against such injury. Video Abstract.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Células-Tronco Mesenquimais / Infarto do Miocárdio Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Células-Tronco Mesenquimais / Infarto do Miocárdio Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article